As smaller, less-rigorous studies have found, the HPV test picked up far more cervical pre-cancers than the Pap smear did, the researchers write in The New England Journal of Medicine. "The paper clearly comes across strongly in favor of HPV testing as a primary screening test," says senior author Eduardo Franco, a cancer researcher at Montreal's McGill University. Only women who test positive for a cancer-causing HPV type would then have a Pap smear, Franco says.
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